Figure 5.

vg distribution of eqIL-10

The ocular and systemic distribution of AAV8-eqIL-10 vgs were quantified via qPCR on tissue recovered following euthanasia from all horses. Each point represents one technical replicate (n = 3), with mean ± standard deviation noted. Findings are portrayed as the average vg/ng of recovered genomic DNA. HD, high-dose treated; LD, low-dose treated; V, vehicle treated. Significance levels were determined between that of the treated and untreated samples using an unpaired t test (ns, p > 0.05; ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001). For the AH and VH, findings are portrayed as the average vg/μL of recovered solution. Significance levels were determined between that of the treated and untreated samples using an unpaired t test (ns, p > 0.05; ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001).