Table 1.
Clinical adverse events observations
| Horse | Dose | Adverse event | Days identifieda |
|---|---|---|---|
| 1. Saline control | not applicable | none | not applicable |
| 2. LD AAV-eqIL-10 (LD 1) | 3.75e−11 vgs | none | not applicable |
| 3. LD AAV-eqIL-10 (LD 2) | 3.75e−11 vgs | conjunctival hyperemia OD aqueous flare (scores 0.5–1)b OD | 35–49 |
| 4. HD AAV-eqIL-10 (HD 1) | 3.75e−12 vgs | keratic precipitates OU | 77–86 |
| 5. HD AAV-eqIL-10 (HD 2) | 3.75e−12 vgs | peripapillary depigmentation OD conjunctival hyperemia OS keratic precipitates OU |
21–86 35 70–86 |
OD, right eye; OS, left eye; OU, both eyes; vg, viral genome.
a
Ocular examinations were performed on days 0, 1, 3, and 7, and then weekly until day 86.
b
Modified SPOTs (semiquantitative preclinical ocular toxicology) scoring system was used to generate numerical scores.