Figure 5.

Distribution of iSNVs among lung, liver, kidney, heart, and intestine metagenomes. Gray segments represent the virus genome. Above each segment, it is indicated which specimen and case each metagenome corresponds to; for example, 46(c18) indicate the segment corresponds to the metagenome retrieved from Specimen 46 of case 18. Ticks on the inner and outer boundaries of segments indicate genome positions (1 tick = 1 kB). Intra‐host polymorphisms are represented by colored dots (red: non‐synonymous substitution; blue: synonymous substitution). Grids on the segments are used to display alternative allele frequencies. Each grid line correspond to 0.2 (20%) abundance units. The lines in the innermost part of the graph (namely “links”) connect polymorphic genome positions affected by same iSNVs. Colored links correspond to iSNVs present in all cases (cyan polymerase D533N; green nucleocapsid D415D; magenta nucleocapsid D415G; orange nucleocapsid D415E; MN908947.3 coordinates). Please see also Figures [Link], [Link], [Link], [Link].