Table 2.
Summary table of the diagnostic accuracy.
| Assay | Pooled analysis results (95% CI) | Heterogeneity | Deek's test | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pooled sensitivity | Pooled specificity | Pooled PLR | Pooled NLR | AUC | DOR | I 2 (%) | p | t | p | |
| Access SARS‐CoV‐2 IgG | 0.78 (0.64−0.87) | 1.00 (0.99−1.00) | 275.20 (82.90−914.00) | 0.22 (0.13−0.38) | 1.00 | 564.28 (229.58−1386.91)a | 0 | 0.56 | −0.53 | 0.618 |
| EDI novel coronavirus COVID‐19 IgG | 0.67 (0.60−0.74) | 0.98 (0.97−0.99) | 36.10 (21.90−59.50) | 0.34 (0.27−0.41) | 0.95 | 85.27 (53.99−134.68) | 55 | < 0.01 | −0.18 | 0.859 |
|
EDI novel coronavirus COVID‐19 IgG (omitting Davidson) |
0.68 (0.60−0.74) | 0.98 (0.97−0.99) | 38.20 (24.10−60.70) | 0.33 (0.26−0.41) | 0.97 | 87.61 (67.43−113.81)a | 32 | 0.13 | 0.25 | 0.806 |
| EDI novel coronavirus COVID‐19 IgM | 0.41 (0.30−0.52) | 0.99 (0.97−1.00) | 47.20 (12.80−173.40) | 0.60 (0.49−0.73) | 0.86 | 49.42 (16.47−148.30) | 76 | < 0.01 | 0.32 | 0.758 |
|
EDI novel coronavirus COVID‐19 IgM (omitting Davidson) |
0.44 (0.33−0.55) | 0.99 (0.98−1.00) | 63.60 (18.40−219.30) | 0.57 (0.46−0.70) | 0.91 | 67.86 (25.55−180.22) | 57 | 0.03 | 1.12 | 0.315 |
| iFlash‐SARS‐CoV‐2 IgG | 0.87 (0.82−0.90) | 1.00 (0.98−1.00) | 195.10 (44.00−865.00) | 0.13 (0.10−0.18) | 0.97 | 652.31 (362.32−1174.41)a | 48 | 0.05 | −2.52 | 0.040b |
| iFlash‐SARS‐CoV‐2 IgM | 0.52 (0.49−0.55) | 0.98 (0.97−0.99) | 18.37 (5.71−59.05) | 0.52 (0.45−0.60) | 0.76 | 36.72 (12.42−108.54) | 87 | < 0.01 | −3.41 | 0.014b |
|
iFlash‐SARS‐CoV‐2 IgM (omitting Han Xiaoyan) |
0.50 (0.41−0.60) | 0.98 (0.96−0.99) | 32.30 (15.70−66.20) | 0.50 (0.42−0.61) | 0.86 | 49.19 (31.92−75.81)a | 51 | 0.06 | −2.37 | 0.064 |
| MAGLUMI 2019‐nCoV IgG | 0.69 (0.62−0.74) | 0.99 (0.97−1.00) | 71.30 (22.80−223.00) | 0.32 (0.26−0.38) | 0.90 | 145.44 (59.37−356.30) | 57 | 0.03 | −1.26 | 0.263 |
|
MAGLUMI 2019‐nCoV IgG (omitting Harritshøj) |
0.66 (0.60−0.72) | 0.99 (0.95−1.00) | 59.30 (13.40−261.50) | 0.34 (0.29−0.40) | 0.83 | 83.80 (42.86−163.85)a | 0 | 0.72 | 0.12 | 0.912 |
| MAGLUMI 2019‐nCoV IgM | 0.55 (0.51−0.59) | 0.97 (0.96−0.98) | 23.77 (4.96−113.88) | 0.45 (0.36−0.57) | 0.59 | 21.59 (14.27−32.67)a | 53 | 0.09 | 0.74 | 0.534 |
| Ortho‐clinical anti‐SARS‐CoV‐2 IgG | 0.86 (0.64−0.96) | 1.00 (0.99−1.00) | 330.20 (69.80−1562.30) | 0.14 (0.04−0.42) | 1.00 | 719.46 (262.34−1973.13)a | 56 | 0.05 | −0.68 | 0.536 |
|
Ortho‐clinical anti‐SARS‐CoV‐2 IgG (omitting Harritshøj) |
0.85 (0.54‐0.96) | 0.99 (0.98‐1.00) | 139.20 (44.90−431.50) | 0.16 (0.04−0.56) | 1.00 | 459.87 (156.30−1353.00)a | 33 | 0.20 | 1.13 | 0.340 |
| Ortho‐clinical anti‐SARS‐CoV‐2 total | 0.88 (0.70−0.96) | 1.00 (0.98−1.00) | 1036.40 (55.80−19258.80) | 0.12 (0.04−0.34) | 1.00 | 1104.60 (395.64−3083.99)a | 33 | 0.18 | −1.28 | 0.256 |
| Siemens SARS‐CoV‐2 total (COV2T) | 0.85 (0.78−0.90) | 1.00 (0.99−1.00) | 521.80 (135.30−2011.80) | 0.15 (0.10−0.22) | 0.99 | 1143.37 (316.49−4130.62) | 91 | < 0.01 | −4.11 | 0.001b |
|
Siemens SARS‐CoV‐2 total (COV2T) (omitting Kundu) |
0.85 (0.78−0.90) | 1.00 (1.00−1.00) | 301.60 (196.80−462.10) | 0.15 (0.10−0.22) | 1.00 | 1581.39 (837.31−2986.72) | 45 | 0.02 | −4.90 | 0.000b |
| Wantai SARS‐CoV‐2 total Ab | 0.93 (0.88−0.96) | 0.99 (0.98−1.00) | 107.80 (50.80−229.00) | 0.07 (0.04−0.12) | 1.00 | 1014.98 (618.48−1665.66)a | 33 | 0.15 | −0.10 | 0.919 |
a
The pooled DOR was calculated with a fixed effects model.
b
Significant publication bias was observed.