Table 3.

System-specific parameters associated with Child-Pugh A liver function.

Parameter	Normal liver function	Child-Pugh A	Proportional coefficient	Source
Hematocrit value	0.46	0.39	0.85	Wong et al. 35
Plasma protein scale factor	1.00	0.85	0.85	Gerner and Scherf-Clavel 36
Albumin	1.00	0.81	0.81	Woitas et al. 37
α1-Acid glycoprotein	1.00	0.60	0.60	Barry et al. 38
Fractional liver mass (L)	2.13	1.47	0.69	Edginton and Willmann 34
Blood flow (L/min)
Portal			0.40	Annet et al. 39
Hepatic arterial			1.30	Annet et al. 39
Renal	1.38	1.21	0.88	Dincer et al. 40
Brain	0.77	0.77	1.00	Edginton and Willmann 34
Other organs			1.75	Edginton and Willmann 34
Enzyme abundance (μmol/L)
CYP2D6	0.40	0.31	0.76	Heimbach et al. 21
CYP3A4	4.32	3.41	0.79	Heimbach et al. 21
Gastric residence time (min)	24.00	28.80	1.20	Heimbach et al. 21