Figure 2.

Sequence similarity network of Sb-PDE and evolutionarily related members of the PHP family of enzymes. Each rectangle represents a unique sequence from the Uniprot database, while each line represents an evolutionary relationship (alignment score) of 85 or greater. Sb-PDE is colored red and labeled. The single protein with a known structure (PDB: 3E38) is colored black and labeled. Proteins annotated as histidinol phosphatases are shown in green. Proteins annotated as phosphotransferases are colored dark blue. The remaining (light blue) proteins are annotated as the PHP-domain or PolIII-domain proteins.