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Active site of No-PDE homologue from B. vulgatus (PDB: 3e38) showing the trivalent metal center where the α- and β-metals activate the nucleophilic water and the γ-metal acts as a Lewis acid to the leaving group. Additional metal ligating residues are not shown for the sake of clarity. The pocket for the leaving group is lined by residues shown in red, while the side ester for a diester substrate would bind in the pocket lined by residues in yellow. Numbering from No-PDE.
