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. 2024 Dec 18;25:1205. doi: 10.1186/s12864-024-11150-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Case study of Aging2Cancer. (A) Genomic alterations of 15 essential genes in LGG younger and older patients. Left panel showed the genomic alteration distributions via oncoprint plot. Right panel showed the difference of genomic alterations between LGG groups via Chi-squared test. (B) The distribution of mutation counts for ATRX gene for LGG younger and older patients. (C) The difference in linear combinations of 10 essential genes expressions between younger and older LGG patients. (D) The relationship between aging and ATRX expression in LGG patients. (E) Violin plot showed the difference of cellular senescence scores between LGG younger and older groups. (F) The correlation coefficients between ATRX and cellular senescence between LGG younger and older groups. (G) Kaplan–Meier curves for overall survival in LGG younger and older patients according to the ATRX mutation status