Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Nov 13;9(12):e00265-24. doi: 10.1128/msphere.00265-24

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Trefry et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

The image shows the effects of VACV strains and TNX-801 on mice via intranasal infection. VACV strains cause severe disease, temperature drops, weight loss, and death, while TNX-801 shows no symptoms and 100% survival. — Infection of C57BL/6 Ifngr^−/− mice at 7.0 log₁₀ PFU/mouse dose with VACV-WR, VACV-IHD, VACV-Lis, VACV-NYCBH, TNX-801, and PBS via intranasal (IN) route (A). Following infection, mice were monitored for disease score (B), body temperature (C), weight loss (D), and survival (E). The target dose for each virus was verified via the plaque assay, and values are provided (A). p-values comparing VACV strains to TNX-801 and mock groups are provided in each graph.