Table 3.

Types of hypersensitivity reactions [7, 8]

Type	Alternate name	Examples	Mediators
I	Allergy (immediate)	• Atopy - Anaphylaxis - Asthma - Allergic rhinitis - Angioedema - Food allergy	IgE
II	Cytotoxic, antibody-dependent	• Erythroblastosis fetalis • Goodpasture syndrome • Autoimmune anemias, thrombocytopenias	IgG, IgM
III	Immune complex disease	• Systemic lupus erythematosus • Serum sickness • Reactive arthritis • Arthus reaction	Aggregation of antigens IgG, IgM Complement proteins
IV	Delayed-type hypersensitivity, cell-mediated, antibody-independent	• Contact dermatitis (e.g. poison ivy) • Tuberculosis skin test • Chronic transplant rejection	T cells, monocytes, macrophages