Table 3.
Unadjusted outcomes of relevant clinical status
| Overall N = 222 |
Familial N = 104 |
Sporadic N = 118 |
P value | OR | 95%CI | |
|---|---|---|---|---|---|---|
| Progressive disease (Yes) |
n = 204 96 (47) |
n = 93 62 (67) |
n = 111 34 (31) |
< 0.001χ | 4.53 | 2.51–8.18 |
| FVC (%) change |
n = 204 -2.07 ± 12.1 |
n = 95 -3.24 ± 15.9 |
n = 109 -1.05 ± 7.08 |
0.116u | - | - |
| DLCO (%) change |
n = 198 -2.55 ± 10.6 |
n = 92 -2.70 ± 12.0 |
n = 106 -2.00 ± 9.26 |
0.524u | - | - |
| FVC (L) change |
n = 204 -0.095 ± 0.31 |
n = 95 -0.12 ± 0.39 |
n = 109 -0.072 ± 0.22 |
0.134u | - | - |
| Lung transplantation (Yes) |
n = 218 33 (15) |
n = 104 22 (21) |
n = 114 11 (10) |
0.018χ | 2.51 | 1.15–5.48 |
| Death (Yes) |
n = 216 43 (20) |
n = 104 24 (23) |
n = 112 19 (17) |
0.261χ | 1.47 | 0.75–2.88 |
|
Radiological Worsening 2y Yes No |
n = 207 69 (33) 138 (67) |
n = 94 45 (48) 49 (52) |
n = 113 24 (21) 89 (79) |
< 0.001X | 3.41 | 1.86–6.24 |
Results are presented as the means ± standard deviations if numerical and as N (%) if categorical. uMann-Whitney U, χChi-Square. OR odds ratio. 95%CI 95% confidence interval