Fig. 2.

General decrease in methylation during pregnancy, with a significant genome-wide hypomethylation in preeclampsia patients near late pregnancy. Box plots showing the mean genomic methylation level of controls and preeclampsia (PE) cases. Means were compared with Wilcoxon rank-sum tests using Bonferroni multiple testing correction. Methylation levels from presymptomatic samples, sampled between 11 and 14 weeks of gestation, show no significant difference. Methylation levels between cases and controls sampled after 20 weeks of gestation show a significantly lower methylation level of cases compared to controls. Significant methylation differences between presymptomatic and symptomatic groups can be observed for both preeclampsia cases and controls