Fig. 3.

Significantly differently methylated regions (DMRs) enable distinct clustering of preeclampsia cases and controls during third trimester pregnancies. Heatmap figures show a hierarchical clustering of samples (columns) from the symptomatic analysis set (A) and the presymptomatic analysis set (B). The clustering is based on the methylation level of the top 250 significant DMRs for the symptomatic set and all 42 DMRs for the presymptomatic set. The sample category, fetal sex, and aspirin treatment are included as additional annotations per sample