Fig. 5.

General genome-wide methylation trends across pregnancy differ between preeclampsia cases and controls. Mean whole genome methylation follows a similar trend for preeclampsia patients and controls across pregnancy duration. At 11–13 weeks of gestation, a lower global methylation is noted for preeclampsia cases (A). The methylation pattern of two preeclampsia-related genes, sFLT-1 (B) and PlGF (C), is slightly different for controls and preeclampsia patients. Smoothing was performed with local polynomial regression fitting, and standard error (SE) is shown as a band