Fig. 3.

PPP mediates STING-facilitated antiviral immune response. A Analysis of glucose metabolomics in spleens from wild-type and STING knockout mice injected with HSV via tail vein. B mRNA expression of inflammatory factors (IFN-β, IL-6, CCL5) in STING-overexpressed KYSE-30 cells transfected with poly(dA:dT). C Levels of TKT, G6PD, R-5P, and GSH in STING-overexpressed KYSE-30 cells treated with poly(dA:dT) and 6-AN or OT (10 mM, TKT inhibitor) for 10 h. D Levels of STING and inflammatory cytokines (IFN-β, CCL5, IL-6) in STING-overexpressed KYSE-30 cells treated with poly(dA:dT) and 6-AN. E mRNA expression of TKT and inflammatory cytokines (IFN-β, CCL5, IL-6) in STING-overexpressed KYSE-30 cells treated with ISD (DNA virus analogue) and OT. Data are mean ± SEM from three biological replicates. * p < 0.05, ** p < 0.01, *** p < 0.001