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. 2024 Dec 18;22:599. doi: 10.1186/s12964-024-01983-2

Fig. 4.

Fig. 4

STING upregulates TKT. A Transcriptome sequencing analysis revealed mRNA expression of key PPP enzymes (TKT, G6PD) in wild-type and STING knockout mice. B mRNA expression of TKT and G6PD in wild-type and STING-overexpressed cells detected by qPCR. C Co-IP using an anti-STING antibody, followed by mass spectrometry to identify proteins interacting with STING. D Interaction between TKT and STING detected by anti-TKT and anti-STING antibodies. E Expression of G6PD and TKT in STING-overexpressing KYSE-30 cells and HSV-infected cells. F IHC staining of STING and TKT in liver tissues from wild-type and STING knockout mice. G TKT enzyme activity and mRNA expression of STING in KYSE-30 cells treated with poly(dA:dT). Data are mean ± SEM from three biological replicates. *** p < 0.001; ns, no significance