Fig. 6.

TKT mediates the antiviral immune response of STING. A Expression and enzyme activity of TKT in control and TKT siRNA KYSE-30 cells. B ELISA detection of antiviral immune factors (IL-6, IFN-β) in control and TKT siRNA KYSE-30 cells with or without poly(dA:dT). C qPCR detection of inflammatory factors (CCL-5, IL-6, IFN-β) in control and TKT siRNA KYSE-30 cells with or without poly(dA:dT). D qPCR detection of inflammatory factors in control and TKT overexpressing KYSE-30 cells with or without poly(dA:dT). E qPCR detection of inflammatory factors in control and STING-knocked down KYSE-30 cells transfected with TKT expressing vector and/or poly(dA:dT). Data are mean ± SEM from three replicates in each group. ** p < 0.01; *** p < 0.001