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Schematic diagram depicting that STING exerts antiviral innate immune response by activating pentose phosphate pathway. DNA virus infection activates the PPP in host cells, thereby initiating STING-mediated antiviral immune response. STING interacts with TKT, a key enzyme in the non-oxidative branch of the PPP, and reduces its ubiquitination via the E3 ubiquitin ligase UBE3A, stabilizing TKT and upregulating PPP
