Table 2.

Regressions exploring the association between hypertension and cognitive function

	Crude model			Model 1			Model2			Model 3			Model 4
	β	95%CI	P	β	95%CI	P	β	95%CI	P	β	95%CI	P	β	95%CI	P
Hypertension
No	Ref			Ref			Ref			Ref			Ref
Yes	−0.982	−1.283, −0.680	< 0.001	−0.640	−0.931, −0.358	< 0.001	−0.666	−0.956, −0.375	< 0.001	−0.699	−0.983, −0.416	< 0.001	−0.640	−0.935, −0.346	< 0.001
Age
< 68				Ref			Ref			Ref			Ref
> = 68				−1.582	−1.803, −1.361	< 0.001	−1.536	−1.771, −1.300	< 0.001	−1.439	−1.666, −1.213	< 0.001	−1.376	−1.601, −1.151	< 0.001
Sex
Male				Ref			Ref			Ref			Ref
Female				0.590	0.387, 0.793	< 0.001	0.608	0.385, 0.831	< 0.001	0.699	0.429, 0.970	< 0.001	0.681	0.405, 0.956	< 0.001
Ethnicity/Race
Non-Hispanic White				Ref			Ref			Ref			Ref
Non-Hispanic Black				−1.397	−1.711, −1.082	< 0.001	−1.416	−1.736, −1.095	< 0.001	−1.289	−1.628, −0.941	< 0.001	−1.385	−1.754, −1.016	< 0.001
Mexican American				−0.766	−1.165, −0.368	< 0.001	−0.799	−1.199, −0.398	< 0.001	−0.829	−1.243, −0.416	0.001	−0.896	−1.327, −0.466	0.001
Other Hispanic				−1.538	−1.874, −1.203	< 0.001	−1.535	−1.864, −1.206	< 0.001	−1.408	−1.744, −1.071	< 0.001	−1.468	−1.842, −1.094	< 0.001
Other Race				−0.755	−1.115, −0.394	< 0.001	−0.701	−1.077, −0.325	0.001	−0.468	−0.884, −0.053	0.031	−0.558	−0.975, −0.140	0.015
Education Level
Below high school				Ref			Ref			Ref			Ref
High school or equivalent				1.022	0.585,1.459	< 0.001	0.998	0.559, 1.437	< 0.001	0.837	0.345, 1.329	0.004	0.796	0.311, 1.282	0.005
College or above				2.436	2.046,2.827	< 0.001	2.420	2.024, 2.816	< 0.001	2.125	1.647, 2.603	< 0.001	2.072	1.562, 2.581	< 0.001
Marital Status
Married/Living with partner				Ref			Ref			Ref			Ref
Widowed/Divorced/Separated/Never married				−0.382	−0.689, −0.075	0.017	−0.382	−0.694, −0.069	0.020	−0.330	−0.651, −0.010	0.045	−0.280	−0.609, 0.050	0.087
BMI
18.5–24.9							Ref			Ref			Ref
< 18.5							−0.482	−1.337, 0.372	0.250	−0.510	−1.546, 0.526	0.299	−0.458	−1.498, 0.583	0.346
25–29.9							0.085	−0.245, 0.415	0.593	0.073	−0.277, 0.422	0.653	0.056	−0.289, 0.401	0.722
> = 30							0.205	−0.151, 0.560	0.242	0.206	−0.143, 0.555	0.217	0.194	−0.159, 0.547	0.246
Vitamin B12
< 148							Ref			Ref			Ref
148–220							0.563	−0.050, 1.176	0.070	0.554	−0.142, 1.251	0.107	0.343	−0.417, 1.103	0.334
> = 220							0.504	−0.040, 1.047	0.067	0.503	−0.063, 1.068	0.076	0.129	−0.429, 0.688	0.613
Physical Activity
Inactive										Ref			Ref
Moderate										0.275	−0.021, 0.571	0.065	0.267	−0.038, 0.572	0.079
Vigorous										0.144	−0.396, 0.684	0.566	0.211	−0.313, 0.735	0.386
Both moderate and vigorous										0.436	0.008, 0.864	0.047	0.395	−0.048, 0.839	0.075
Short-term Alcohol Intake, gm, N (%)
< = 28 (Male) / < = 14 (Female)										Ref			Ref
> 28 (Male) / > 14 (Female)										0.192	−0.269, 0.654	0.374	0.184	−0.286, 0.654	0.399
Alcohol Drinks > = 12 in the Past 12 Months, N (%)
No										Ref			Ref
Yes										0.590	0.315, 0.864	< 0.001	0.578	0.305, 0.852	< 0.001
Smoking
Never										Ref			Ref
Former										−0.285	−0.628, 0.057	0.093	−0.304	−0.646, 0.038	0.076
Now										−0.596	−1.015, −0.177	0.010	−0.590	−1.019, −0.160	0.013
Log_sMMA													−0.476	−0.725, −0.227	0.002
R-squared	0.0370			0.3120			0.3130			0.3290			0.3360
Adjusted R-squared	0.0367			0.311			0.3100			0.3261			0.3329
F-change				825.225, p < 0.001			5.886, p = 0.344			34.814, p = 0.017			18.703, p = 0.002

Crude model: Non-adjusted

Model 1: Adjusted for age, sex, ethnicity, education level, marital status

Model 2: Adjusted for age, sex, ethnicity, education level, marital status, BMI, Vitamin B12

Model 3: Adjusted for age, sex, ethnicity, education level, marital status, BMI, Vitamin B12, physical activity, short-term alcohol intake, alcohol drinks > = 12 in the past 12 months, smoking

Model 4: Adjusted for age, sex, ethnicity, education level, marital status, BMI, Vitamin B12, physical activity, short-term alcohol intake, alcohol drinks > = 12 in the past 12 months, smoking, Log_sMMA

BMI Body mass index, Log_sMMA The logarithm of sMMA