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. 2024 Dec 19;43:326. doi: 10.1186/s13046-024-03245-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — scRNA-seq reveals various cell types involved in intestinal-type GC carcinogenesis. A Workflow of sample processing and scRNA-seq (left). AB/PAS and HID/AB staining images of CIM and IIM. Scale bar, 250 μm (right). B UMAP plot of single cells annotated by major cell types (left) and samples (middle). The percentages of different cell types in CIM, IIM and EGC samples are shown (right). C Heatmap of the DEGs (rows) corresponding to major cell types (columns). D UMAP of epithelial cells colored according to inferred cell type (left). Fractions of epithelial cell clusters detected in each group (right). Dot plot of different marker genes of epithelial cell clusters (bottom). E UMAP of T cells colored according to inferred cell type (left). Fractions of T-cell clusters detected in each group (right). F UMAP of MP clusters colored according to inferred cell type (left). Fractions of MP clusters detected in each group (middle). Violin plots of different marker genes of MP clusters (right)