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. 2024 Dec 19;43:326. doi: 10.1186/s13046-024-03245-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — FOLR2⁺ macrophages play crucial roles in antitumor immunity. A Bubble plot of phagocytosis-related genes in MP clusters. B KEGG analysis of DEGs inFOLR2⁺macrophages.C Representative flow cytometry plots of HLA-DR expression in FOLR2⁺ or FOLR2^- MDMs from the same healthy donor (n=3). D Landscape of the metabolic pathways in different macrophage clusters. The color represents the metabolic value.E Pseudotime ordering of MP cells into a major trajectory with two bifurcations. The color gradient denotes the pseudotime score (left). Pseudotime trajectory of MP cells presented according to cell clusters for each group (right).F Representative mIHC images of FOLR2, CD68 and cytokeratin (CK) in EGC samples. Scale bar, 50 μm.G Representative mIHC images of CHI3L1, CD68 and CK in EGC samples. Scale bar, 50 μm. H Heatmap of the differentially predicted transcriptional regulons in the five macrophage clusters