Table 1.
List of homing receptor markers studied by flow cytometry on human stimulated T cells.
| Marker | Receptor type | Ligand | Function | Marker-expressing cells | Reference |
|---|---|---|---|---|---|
| CD197 (CCR7) | Chemokine receptor | CCL19, CCL21 | Entry into secondary lymphoid organs | Naïve T cells, memory T cell subsets | Brinkman 201350 |
| CCR10 | Chemokine receptor | CCL27, CCL28 | Entry into skin tissue | CD4+ T cells | Tubo 2011, Sigmundsdottir 200751,52 |
| CD185 (CXCR5) | Chemokine receptor | CXCL13 | Entry into follicles of secondary lymphoid organs | Follicular helper T cells (Tfh), activated CD4 T cells | Chu 201953 |
| CDw199 (CCR9) | Chemokine receptor | CCL25 | Entry into gut tissue, mucosal tissue | T cells | Mora 200354 Papadakis 200355 |
| CD194 (CCR4) | Chemokine receptor | CCL17 | Entry into inflamed skin tissue | CD4+ T cells | Campbell 200756 |
| CD196 (CCR6) | Chemokine receptor | CCL20 | Entry into inflamed epithelial tissue, gut tissue | Immature DC, Th17, Tcm and Tem, B cells, NKT cells | Ito 201157 |
| CD186 (CXCR6) | Chemokine receptor | CXCL16 | Entry into inflamed tissues, liver, and lungs | T cells, NK cells, NKT cells | Tse 2014, Wein 201958,59 |
| CXCR3 | Chemokine receptor | CXCL9, CXCL10, CXCL11 | Entry into inflamed tissues | T cells, NK cells | Groom 201960 |
| CD103 | Integrin | E-cadherin | Entry into epithelial tissues (lung, skin, human liver, gut) | T cells, DC | Mackay 2013, Thopam 201819,61 |
| CD161 (KLRB1) | C-type lectin | LLT1 | Entry into inflamed tissue, enriched in T cells from gut and liver | CD4+ and CD8+ T cells, NK cells, NKT cells, monocytes, and dendritic cells | Konduri 202062 |