Fig. 8.

Construction and analysis of the potential herbal drug–gene network. A Chinese medicine drug–target gene network. The size of each node in the network indicates the size of its degree value. The connection line indicates that each node is interconnected. B Expression levels of TPP1, TLR4, and RIPK2 mRNA in serum samples from 10 DFU and 10 DM patients, as well as in foot skin tissue (ulcerated and corresponding distal normal tissue) from 5 DFU patients, were detected by qRT-PCR. C Expression levels of TPP1, TLR4, and RIPK2 in foot skin tissue (ulcerated and corresponding distal normal tissue) from 5 DFU patients were assessed by immunohistochemistry