Table 1.
General patient characteristics and clinical pregnancy outcomes after a fresh cycle in the NOR and DOR groups
| Variable | NOR (n = 91) | DOR (n = 91) | P value |
|---|---|---|---|
| Age, years | 33.76 ± 0.36 | 34.26 ± 0.38 | 0.229 |
| Body mass index, kg/m2 | 22.23 ± 0.35 | 22.30 ± 0.33 | 0.612 |
| Infertility diagnosis | 1.000 | ||
| Primary infertility | 60 (65.9) | 60 (65.9) | |
| Secondary infertility | 31 (34.1) | 31 (34.1) | |
| Duration of infertility, years | 3.25 ± 0.30 | 3.91 ± 0.32 | 0.057 |
| Male factor infertility | 70 (76.9) | 71 (78.0) | 0.859 |
| Baseline FSH, mIU/mL | 6.13 ± 0.20 | 10.05 ± 0.47 | < 0.001* |
| Baseline AMH, ng/mL | 3.38 ± 0.17 | 0.61 ± 0.03 | < 0.001* |
| Antral follicle count | 14.32 ± 0.61 | 3.98 ± 0.28 | < 0.001* |
| Baseline LH, IU/L | 3.62 ± 0.20 | 3.46 ± 0.17 | 0.592 |
| Baseline E2, pmol/L | 107.30 ± 12.81 | 161.07 ± 27.05 | 0.018* |
| Baseline P, ng/mL | 1.23 ± 0.08 | 2.95 ± 1.56 | 0.579 |
| Fertilization method | 0.006* | ||
| IVF | 41 (45.0) | 56 (61.5) | |
| ICSI | 44 (48.4) | 35 (38.5) | |
| IVF + ICSI | 6 (6.6) | 0 (0) | |
| Duration of stimulation, days | 10.35 ± 0.17 | 10.23 ± 0.27 | 0.572 |
| Gonadotropins dose, IU | 2523.43 ± 85.56 | 2992.92 ± 148.68 | 0.034* |
| LH on hCG day, IU/L | 38.89 ± 36.51 | 20.28 ± 17.05 | 0.012* |
| E2 on hCG day, pmol/L | 10986.32 ± 647.84 | 3739.22 ± 298.61 | < 0.001* |
| P on hCG day, ng/mL | 2.45 ± 0.12 | 2.18 ± 0.38 | < 0.001* |
| Endometrial thickness, mm | 10.39 ± 0.16 | 9.35 ± 0.23 | 0.004* |
| No. of oocytes retrieved | 12.04 ± 0.58 | 3.79 ± 0.26 | < 0.001* |
| Normal fertilization rate | 0.67 ± 0.02 | 0.62 ± 0.04 | 0.928 |
| Cleavage rate | 0.98 ± 0.01 | 0.94 ± 0.02 | 0.420 |
| Available embryo rate | 0.38 ± 0.03 | 0.41 ± 0.04 | 0.890 |
| High quality embryo rate | 0.47 ± 0.03 | 0.46 ± 0.04 | 0.850 |
| No. of embryos transferred | < 0.001* | ||
| 1 | 2/47 (4.3) | 20/45 (44.4) | |
| 2 | 45/47 (95.7) | 25/45 (55.6) | |
| Type of embryo transferred | 0.144 | ||
| Cleavage embryo | 47/47 (100.0) | 43/45 (95.6) | |
| Blastocyst | 0/47 (0.0) | 2/45 (4.4) | |
| Biochemical pregnancy | 25/47 (53.2) | 22/45 (48.9) | 0.835 |
| Clinical pregnancy | 25/47 (53.2) | 21/45 (46.7) | 0.677 |
| Pregnancy loss | 3/25 (12.0) | 4/21 (19.0) | 0.686 |
| Live birth | 0.381 | ||
| Singleton live birth | 17/47 (36.2) | 14/45 (31.1) | |
| Multiple live births | 5/47 (10.6) | 3/45 (6.7) |
Note Continuous data are reported as the mean ± standard deviation. Categorical data are reported as n (%). The Mann‒Whitney U test was used to analyze continuous data, and the chi‒square test or Fisher’s exact test was used to analyze categorical data. NOR = normal ovarian reserve; DOR = diminished ovarian reserve. * P < 0.05