Fig. 8.

a Molecular structures of NIR-II polymer (m-PBTQ4F), short-rigid polymer (CN-PPV), and amphiphilic polymer (PSMA and PS-PEG-COOH), and the preparation and morphology modulation of NIR-II Pdots by blending amphiphilic polymer and short-rigid polymer during preparation. b NIR-II fluorescence image of a mouse acquired in prostrate and supine. c In vivo NIR-II fluorescence images of cerebral vasculature of mice with an intact skull and scalp, together with the quantitative comparison of vessel-length and vessel-branch in the cerebral vasculature between wild-type and tumor-bearing mice by using vascular segmentation and quantification algorithm. Reproduced with permission from Wu et al. [115]