Table 2.

Recommendations, rationale, and potential actions for gastric cancer prevention and control in Chile (and the Americas).

Adapted from Riquelme et al. [69]

Recommendation	Rationale	Potential implementation actions
Strengthen population-based cancer registries	As the epidemiology of GC is changing in the Americas, periodical, and detailed registry-based analyses are required The Chilean Cancer Law now requires a national cancer registry. High-quality and comprehensive cancer registries will ensure that policymakers have accurate and timely data on incidence, treatment, and survivorship to make decisions based on evidence	Implement a sustainable registry with good national coverage and adequate funding Establish new population-based registries in high-risk areas with no coverage
Support development and dissemination of standards for quality care	High quality must be a requirement for health care providers in Chile	In collaboration with the Ministry of Health, clinical and academic societies promote multidisciplinary and establish combined operational guidelines and promote consistent reporting of histopathologic findings
Enable training of health care workforce	Trained health providers can effectively limit morbidity and mortality associated with GC	Establish high-level training for health providers in areas of H. pylori eradication and endoscopy practice and biopsy taking
Establish H. Pylori management registration and a surveillance system of antibiotic resistance	Promote quadruple clarithromycin-based therapies. Registry data of H. pylori for the selection of regimens to be used in each population based on studies of antibiotic resistance in the same population	Establish a large-scale long-term prospective registry of H. pylori-positive patients receiving eradication therapy
Perform endoscopic campaigns in high-risk populations (e.g. rural areas), focusing on individuals with major risk factors	Mobile screening services have served to expand access to cancer screening in diverse contexts as individuals in lower socioeconomic and indigenous groups exhibit higher risk of GC incidence and mortality	Perform endoscopic campaigns focused on high-risk individuals (i.e., adults aged ≥ 50 years, male sex, smokers, family history of GC) and ideally symptomatic
Strengthen strategies to reduce salt (sodium) intake	High salt intake increases the risk of GC by synergizing with the pathogenic effects of chronic H. pylori infection	Adopt WHO recommendations for salt intake reduction to reinforce salt reduction interventions in primary-care settings