Fig. 3.

THBS1 expression in human inner ear organoids. THBS1 is expressed in the human inner ear organoids. Chondrocytes exhibit a high expression for this gene. The dataset plotted consists of human pluripotent stem cells differentiated into complex inner ear tissue [18]. The left panel illustrates the expression of THBS1 in the single-cell and single-nucleus RNA sequence data from the differentiated inner ear organoids. The X axis displays the uniform manifold approximation and projection (UMAP) 1 which is used for dimension reduction and on the Y axis UMAP 2. The scale bar displays normalized gene expression levels which range from low (yellow) to high (red) that have been adjusted for sequence depth. The right panel displays the locations of specific inner ear cell types with color codes