Table 3.
Characteristics of the 250 training fractions and their results of univariate and multivariate analyses
| Characteristics | ARS = 0 (n = 219) |
ARS = 1 (n = 31) |
Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | |||
| Gender (%) | ||||||||
| Male | 156 (71.2) | 23 (74.2) | 1.16 | (0.51 ~ 2.89) | 0.73 | |||
| Female | 63 (28.8) | 8 (25.8) | ||||||
| Age (mean (SD)) | 57.1 (13.6) | 22.6 (2.69) | 0.70 | (0.47 ~ 1.01) | 0.06 | |||
| BMI (mean (SD)) | 23.1 (2.57) | 21.24 (2.05) | 0.85 | (0.57 ~ 1.23) | 0.39 | |||
| Distance (mean (SD)) | 4.81 (2.03) | 5.09 (2.01) | 1.14 | (0.80 ~ 1.61) | 0.47 | |||
| PTVvol (mean (SD)) | 1060 (175) | 1120 (171) | 1.36 | (0.96 ~ 1.90) | 0.075 | 1.77 | (1.17 ~ 2.69) | 6.8e-3 |
| HI (mean (SD)) | 0.0764 (0.0291) | 0.0839 (0.0311) | 1.22 | (0.88 ~ 1.61) | 0.19 | 6.06 | (2.93 ~ 14.8) | 1.0e-5 |
| CI (mean (SD)) | 0.901 (0.0252) | 0.899 (0.0247) | 0.95 | (0.68 ~ 1.34) | 0.70 | |||
| T_stage (%) | ||||||||
| T2 | 14 (6.4) | 0 (0.0) | Ref | Ref | Ref | |||
| T3 | 161 (73.5) | 19 (61.3) | > 1000 | (< 0.001 ~ > 1000) | 0.99 | |||
| T4 | 44 (20.1) | 12 (38.7) | > 1000 | (< 0.001 ~ > 1000) | 0.99 | |||
| N_stage (%) | ||||||||
| N0 | 54 (24.7) | 5 (16.1) | Ref | Ref | Ref | |||
| N1 | 56 (25.6) | 8 (25.8) | 1.54 | (0.48 ~ 5.38) | 0.47 | |||
| N2 | 109 (49.8) | 18 (58.1) | 1.78 | (0.67 ~ 5.63) | 0.28 | |||
| MRF (%) | ||||||||
| Negative | 166 (75.8) | 21 (67.7) | Ref | Ref | Ref | |||
| Positive | 53 (24.2) | 10 (32.3) | 1.49 | (0.64 ~ 3.30) | 0.34 | |||
| EMVI (%) | ||||||||
| Negative | 159 (72.6) | 17 (54.8) | Ref | Ref | Ref | |||
| Positive | 60 (27.4) | 14 (45.2) | 2.18 | (0.98 ~ 4.75) | 0.06 | |||
| Neo_RT (%) | > 1000 | (< 0.001 ~ > 1000) | 0.98 | |||||
| No | 21 (9.6) | 0 (0.0) | Ref | Ref | Ref | |||
| Yes | 198 (90.4) | 31 (100) | > 1000 | (< 0.001 ~ > 1000) | 0.99 | |||
| Chem (%) | - | |||||||
| No | 32 (14.6) | 3 (9.7) | Ref | Ref | Ref | |||
| Yes | 187 (85.4) | 28 (90.3) | 1.60 | (0.53 ~ 6.95) | 0.46 | |||
| IMRT/VMAT (%) | ||||||||
| IMRT | 83 (37.9) | 13 (41.9) | Ref | Ref | Ref | |||
| VMAT | 136 (62.1) | 18 (58.1) | 0.85 | (0.40 ~ 1.85) | 0.67 | |||
| Frac_dose (mean (SD)) | 2.91 (1.41) | 3.16 (1.49) | 1.82 | (0.88 ~ 1.91) | 0.18 | 45.37 | (5.74 ~ 469) | 6.1e-4 |
| Diff_daytime (mean (SD)) | 4.90 (3.14) | 5.97 (3.14) | 3.88 | (0.88 ~ 19) | 0.08 | |||
| Passed_day (mean (SD)) | 16.6 (14.7) | 17.6 (13.0) | 1.07 | (0.74 ~ 1.52) | 0.72 | |||
| Accumulated_dose (mean (SD)) | 16.8 (13.8) | 20.9 (12.8) | 1.34 | (0.92 ~ 1.96) | 0.12 | 2.29 | (1.35 ~ 4.14) | 3.5e-3 |
ARS: The ART requirement score, OR: Odd ratio, CI: Confidence interval, SD: standard deviation