Table 2.
Characteristics at baseline in each HRA group
| 0 HRA | 1 HRA | ≥ 2 HRA | p | |
|---|---|---|---|---|
| n | 215 | 113 | 43 | |
| Drug (%) | 0.535 | |||
| PI plus IMiDs | 116 (58.0) | 58 (52.3) | 22 (52.4) | |
| CD38-based | 36 (18.0) | 18 (16.2) | 10 (23.8) | |
| PI or IMiDs | 48 (24.0) | 35 (31.5) | 10 (23.8) | |
| Unknown | 15 | 2 | 1 | |
| Sex (%) | 0.011 | |||
| Female | 74 (34.4) | 48 (42.5) | 25 (58.1) | |
| Male | 141 (65.6) | 65 (57.5) | 18 (41.9) | |
| Age | 0.828 | |||
| ≥ 65 | 77 (35.8) | 44 (38.9) | 15 (34.9) | |
| < 65 | 138 (64.2) | 69 (61.1) | 28 (65.1) | |
| MM Type | 0.035 | |||
| IgA | 38 (17.8) | 33 (29.2) | 9 (20.9) | |
| IgG | 92 (43.0) | 41 (36.3) | 21 (48.8) | |
| IgD | 7 (3.3) | 13 (11.5) | 3 (7.0) | |
| Light Chain Only | 51 (23.8) | 17 (15.0) | 7 (16.3) | |
| Non-secretory | 25 (11.7) | 9 (8.0) | 3 (7.0) | |
| Biclonal | 1 (0.5) | 0 (0.0) | 0 (0.0) | |
| Unknown | 1 | 0 | 0 | |
| ECOG Score (%) | 0.745 | |||
| 0–1 | 123 (57.2) | 60 (53.1) | 23 (53.5) | |
| ≥ 2 | 92 (42.8) | 53 (46.9) | 20 (46.5) | |
| Transplantation (%) | 0.857 | |||
| Yes | 43 (21.5) | 22 (19.8) | 10 (23.8) | |
| No | 157 (78.5) | 89 (80.2) | 32 (76.2) | |
| Unknown | 15 (7.0) | 2 (1.8) | 1 (2.3) | |
| ISS stage (%) | 0.003 | |||
| 1 | 70 (33.5) | 24 (21.6) | 5 (11.9) | |
| 2 | 66 (31.6) | 32 (28.8) | 11 (26.2) | |
| 3 | 73 (34.9) | 55 (49.5) | 26 (61.9) | |
| Unknown | 6 | 2 | 1 | |
| RISS stage (%) | < 0.001 | |||
| 1 | 67 (33.0) | 18 (16.8) | 0 (0.0) | |
| 2 | 125 (61.6) | 74 (69.2) | 16 (38.1) | |
| 3 | 11 (5.4) | 15 (14.0) | 26 (61.9) | |
| Unknown | 12 | 6 | 1 | |
| BMPC% | < 0.001 | |||
| < 50% | 178 (87.7) | 83 (74.1) | 26 (61.9) | |
| ≥ 50% | 25 (12.3) | 29 (25.9) | 16 (38.1) | |
| Unknown | 12 | 1 | 1 | |
| LDH (%) | 0.2 | |||
| ≥ 250 | 26 (12.2) | 20 (17.9) | 9 (20.9) | |
| < 250 | 187 (87.8) | 92 (82.1) | 34 (79.1) | |
| Unknown | 2 | 1 | 0 | |
| Cr (%) | 0.171 | |||
| ≥ 177 | 32 (14.9) | 23 (20.4) | 11 (25.6) | |
| < 177 | 183 (85.1) | 90 (79.6) | 32 (74.4) | |
| Ca (%) | 0.002 | |||
| ≥ 2.75 | 17 (7.9) | 10 (8.8) | 11 (25.6) | |
| < 2.75 | 198 (92.1) | 103 (91.2) | 32 (74.4) | |
| HGB (%) | < 0.001 | |||
| ≥ 100 | 136 (63.3) | 48 (42.5) | 12 (27.9) | |
| < 100 | 79 (36.7) | 65 (57.5) | 31 (72.1) |
ECOG Score Eastern Cooperative Oncology Group Score; ISS stage International Staging System; RISS stage Revised International Staging System; BMPC% Bone marrow plasma cell percentage; LDH: Lactate dehydrogenase; Cr: Creatinine; Ca: Calcium; HGB Hemoglobin