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. 2002 Jun 7;3:16. doi: 10.1186/1471-2474-3-16

Table 2.

Effect of 1,25-(OH)₂D₃ on Osteoclastic parameters in rat tibial trabecular bone

Exp	Dose	Time	N.Oc/T.Ar (#/mm²)		N.Oc/B.Pm (#/mm)		N.ApOc/T.Ar (#/mm²)
			Vehicle	1,25-(OH)₂D₃	Vehicle	1,25-(OH)₂D₃	Vehicle	1,25-(OH)₂D₃

1	1 × 10 μg/kg	1 d	63.1 ± 2.0	61.7 ± 2.9	6.0 ± 0.5	6.4 ± 0.8	0.7 ± 0.3	1.0 ± 0.6
2	3 × 10 μg/kg	4 d	76.7 ± 2.4	65.7 ± 3.8	7.5 ± 0.1	6.3 ± 0.3	1.0 ± 0.6	11.7 ± 0.9^*
3	3 × 2 μg/kg	4 d	75.0 ± 6.3	111.0 ± 2.0^*	7.0 ± 0.3	9.7 ± 5.3^*	0.3 ± 0.3	10.3 ± 0.7^*
		6 d	85.1 ± 9.5	41.3 ± 12.9^*	8.4 ± 0.5	3.2 ± 1.1^*	1.0 ± 0.6	5.0 ± 0.6^*
		9 d	91.9 ± 10.	98.4 ± 9.8	8.8 ± 0.7	8.8 ± 0.6	0.7 ± 0.3	0.7 ± 0.3
		13 d	9	81.1 ± 4.5	8.9 ± 1.2	6.7 ± 0.7	0.7 ± 0.3	0.3 ± 0.3
		17 d	71.0 ± 5.3	73.9 ± 2.6	6.5 ± 0.2	6.5 ± 0.4	0.7 ± 0.3	1.0 ± 0.6
			73.5 ± 2.2
4	3 × 0.2 μg/kg	4 d	39.2 ± 4.9	33.4 ± 3.0	3.5 ± 0.3	3.9 ± 0.2	0.4 ± 0.2	0.6 ± 0.2
		6 d	32.9 ± 2.4	45.1 ± 4.1^*	3.8 ± 0.3	5.1 ± 0.7^*	0.6 ± 0.2	1.0 ± 0.3
		8 d	37.6 ± 5.6	23.4 ± 2.1^*	5.2 ± 0.7	3.1 ± 0.2^*	0.4 ± 0.2	1.6 ± 0.2^*
		10 d	35.5 ± 3.4	40.9 ± 3.5	5.2 ± 0.5	4.6 ± 0.6	0.4 ± 0.2	0.8 ± 0.4
		12 d	36.9 ± 5.0	39.0 ± 7.9	4.6 ± 0.3	4.5 ± 0.4	0.4 ± 0.2	0.6 ± 0.2
		14 d	41.1 ± 3.9	37.5 ± 1.3	5.7 ± 0.5	4.9 ± 0.4	0.2 ± 0.2	0.4 ± 0.2

All values are mean ± SE, ^*: P < 0.05

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