Table 3.

Effect of 1,25-(OH)₂D₃ on osteoclastic parameters in fourth lumbar vertebral trabecular bone

Exp	Dose	Time	N.Oc/T.Ar (#/mm2)		N.Oc/B.Pm (#/mm)		N.ApOc/T.Ar (#/mm2)
			Vehicle	1,25-(OH)2D3	Vehicle	1,25-(OH)2D3	Vehicle	1,25-(OH)2D3
2	3 × 10 μg/kg	4 d	33.9 ± 5.0	66.4 ± 5.5*	3.9 ± 0.7	7.7 ± 1.0*	0	4.6 ± 1.3*
3	3 × 2 μg/kg	4 d	31.0 ± 1.7	56.3 ± 3.3*	3.5 ± 0.4	6.9 ± 0.4*	0.5 ± 0.3	3.1 ± 0.4*
		6 d	35.0 ± 4.2	16.7 ± 0.6*	4.1 ± 0.5	3.3 ± 0.1*	0.7 ± 0.2	3.5 ± 0.3*
		9 d	30.6 ± 7.3	33.9 ± 4.7	3.8 ± 0.8	3.9 ± 0.7	0.7 ± 0.2	0.7 ± 0.2
		13 d	26.7 ± 2.4	46.9 ± 4.8*	2.9 ± 0.4	5.1 ± 0.3*	0.7 ± 0.2	1.2 ± 0.4
		17 d	30.3 ± 5.0	44.0 ± 4.5	3.5 ± 0.3	4.6 ± 0.6	0.5 ± 0.2	1.0 ± 0.3
4	3 × 0.2 μg/kg	4 d	28.8 ± 1.9	27.3 ± 1.9	3.0 ± 0.2	2.7 ± 0.2	0.2 ± 0.2	0
		6 d	28.2 ± 1.5	27.1 ± 2.6	3.0 ± 0.1	3.0 ± 0.2	0.2 ± 0.2	0
		8 d	26.9 ± 2.8	29.2 ± 2.2	2.9 ± 0.2	3.2 ± 0.4	0	0.4 ± 0.2
		10 d	29.4 ± 2.4	31.7 ± 2.3	3.7 ± 0.1	3.1 ± 0.3	0.2 ± 0.2	0.4 ± 0.2
		12 d	31.5 ± 2.7	32.5 ± 3.3	3.3 ± 0.3	3.6 ± 0.3	0.2 ± 0.2	0.2 ± 0.2
		14 d	30.6 ± 3.2	29.8 ± 2.7	3.5 ± 0.3	3.5 ± 0.3	0	0.2 ± 0.2

All values are mean ± SE, ^*: P < 0.05