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. 2024 Dec 19;22:770. doi: 10.1186/s12951-024-03032-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Accelerated recovery from post-hindlimb ischemia using “Engage & Evasion” approach. (A) Schematic experimental protocol. (B&C) Laser Doppler imaging with perfusion ratio quantification (n = 6). * for comparison between DV/MV⁴⁷ and MV⁴⁷ group; # for comparison between DV/MV⁴⁷ and DV group. (D) Representative H&E images. Scale bar = 50 μm. (E&F) Masson’s trichrome staining with quantification depicting interstitial fibrosis (n = 6). Scale bar = 50 μm. (G&H) IHC staining for CD31 with corresponding quantification. Blue arrowheads indicate CD31⁺ capillaries (n = 4). Scale bar = 25 μm. Statistical evaluations were conducted using either two-way ANOVA or one-way ANOVA. Results were presented as mean ± SEM. (*# P < 0.05; ***### P < 0.001; ns: not significant)