Table 2.
Results various definitions of chronic pain, responders only
| Definitions of chronic pain | Incidence n (%) * | EQ-5D-5 L index** Median (IQR) chronic pain vs. no chronic pain |
P (Wilcox. Test) | Hindrance due to pain Median (IQR) chronic pain vs. no chronic pain |
P (Wilcox. Test) |
|---|---|---|---|---|---|
| Day 90 NRS ≥ 1 (Primary outcome) | 559 (67.8%) |
0.82 (0.74–0.92) Vs. 1.00 (0.89–1.00) |
< 0.001 |
Day 62–90 1.00 (0.00–2.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 90 persisting pain NRS ≥ 1 | 435 (64.3%) |
0.81 (0.73–0.89) Vs. 1.00 (0.89 -1.00) |
< 0.001 |
Day 62–90 1.00 (1.00– 2.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 90 NRS ≥ 4 | 200 (24.2%) |
0.75 (0.65–0.85) Vs. 0.89 (0.81 -1.00) |
< 0.001 |
Day 62–90 2.00 (1.00–2.00) Vs. 1.00 (0.00–1.00) |
<0.001 |
| Day 90 persisting pain NRS ≥ 4 | 153 (22.6%) |
0.74 (0.64–0.81) Vs. 0.89 (0.81–1.00) |
< 0.001 |
Day 62–90 2.00 (1.00–2.00) Vs. 0.00 (0.00–1.00) |
< 0.001 |
| Day 180 NRS ≥ 1 | 393 (58.2%) |
0.85 (0.75–1.00) Vs. 1.00 (0.89–1.00) |
< 0.001 |
Day 152–180 1.00 (0.00–1.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 180 persisting pain NRS ≥ 1 | 308(54.2%) |
0.85 (0.74–0.89) Vs. 1.00 (0.89–1.00) |
< 0.001 |
Day 152–180. 1.00 (0.00–1.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 180 NRS ≥ 4 | 164 (24.3%) |
0.78 (0.67–0.88) Vs. 1.00 (0.85–1.00) |
< 0.001 |
Day 152–180 1.00 (1.00–2.00) Vs. 0.00 (0.00–1.00) |
< 0.001 |
| Day 180 persisting pain NRS ≥ 4 | 123 (21.7%) |
0.75 (0.64–0.85) Vs. 1.00 (0.85–1.00) |
< 0.001 |
Day 152–180 1.00 (1.00–2.00) Vs. 0.00 (0.00–1.00) |
< 0.001 |
* Number and percentage of patients suffering from chronic pain with previous given definitions
** A lower EQ-5D-5 L index correlates with lower quality of life