Table 3.
Results various definitions of chronic pain, responders and non-responders using MICE
| Definitions of chronic pain | Incidence (%) * | EQ-5D-5 L index** Median (IQR) chronic pain Vs. no chronic pain |
P
(Wilcox. Test) |
Hindrance due to pain Median (IQR) Chronic pain Vs. no chronic pain |
P
(Wilcox. Test) |
|
|---|---|---|---|---|---|---|
| Day 90 NRS ≥ 1 (Primary outcome) | 65.3% |
0.82 (0.74–0.92) Vs. 1.00 (0.89–1.00) |
< 0.001 | Day 62–90 |
1.00 (0.00–2.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 90 persisting pain NRS ≥ 1 | 56.5% |
0.81 (0.72–0.89) Vs. 1.00 (0.89–1.00) |
< 0.001 | Day 62–90 |
1.00 (1.00–2.00) Vs. 0.00(0.00–0.00) |
< 0.001 |
| Day 90 NRS ≥ 4 | 25.2% |
0.75 (0.64–0.85) Vs. 0.89 (0.81–1.00) |
< 0.001 | Day 62–90 |
2.00 (1.00–2.00) Vs. 1.00 (0.00–1.00) |
< 0.001 |
| Day 90 persisting pain NRS ≥ 4 | 23.8% |
0.74(0.64–0.81) Vs. 0.89 (0.81–1.00) |
< 0.001 | Day 62–90 |
2.00 (1.00–2.00) Vs. 0.00 (0.00–1.00) |
< 0.001 |
| Day 180 NRS ≥ 1 | 56.3% |
0.85 (0.75–1.00) Vs. 1.00 (0.88–1.00) |
< 0.001 | Day 152–180 |
1.00 (0.00–1.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 180 persisting pain NRS ≥ 1 | 46.0% |
0.85 (0.74–0.89) Vs. 1.00 (0.89–1.00) |
< 0.001 | Day 152–180 |
1.00 (0.00–1.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 180 NRS ≥ 4 | 26.6% |
0.78 (0.67–0.89) Vs. 1.00 (0.85–1.00) |
< 0.001 | Day 152–180 |
1.00 (1.00–2.00) Vs. 0.00 (0.00–0.00) |
< 0.001 |
| Day 180 persisting pain NRS ≥ 4 | 23.3% |
0.75 (0.64–0.85) Vs. 1.00 (0.85–1.00) |
< 0.001 | Day 152–180 |
1.00 (1.00–2.00) Vs. 0.00 (0.00–1.00) |
< 0.001 |
* Percentage of patients suffering from chronic pain with previous given definitions
** A lower EQ-5D-5 L index correlates with lower quality of life