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. 2024 Dec 19;19(12):e0313841. doi: 10.1371/journal.pone.0313841

Table 2. General characteristics of the included studies (n = 18).

Reference publication year Country Study Design population clowns practitioner Timing of intervention Forms of intervention conclusion mark
Ben-Pazi H, et al. [16] 2017 Italy Randomized controlled trial A Medical clowns puncture therapy Cognitive responses;
Empowerment;
Emotional reflection;
Felluga M, et al.[17] 2016 Italy quasi-randomized controlled trial A Medical clowns puncture therapy Cognitive responses;
Divert attention;
①②
Goldberg A, et al [18] 2014 Israel Randomized controlled tria A Medical clowns puncture therapy Divert attention ①②
Kristensen HN, et al. [19] 2018 Denmark Controlled clinical trial A Medical clowns puncture therapy Cognitive responses;
Divert attention;
Meiri N, et al.[20] 2015 United States Randomized controlled tria A Medical clowns puncture therapy Divert attention; ①②④
NingXuemei,et al. [21] 2023 China Randomized controlled tria A Medical clowns puncture therapy Divert attention ①②④
Yang Fan, et al.[22] 2022 China Randomized controlled tria A Medical clowns puncture therapy Cognitive responses;
Divert attention;
Guided imagery;
①④
Dionigi A, et al. [23] 2014 Italy Randomized controlled tria B Medical clowns perioperative period Divert attention;
Markova G,et al. [24] 2021 Germany Randomized controlled tria B Medical clowns perioperative period Guided imagery;
Divert attention;
Vagnoli L, et al. [25] 2005 Italy Randomized controlled tria B Medical clowns perioperative period Guided imagery;
Divert attention
Cheng Zongyan, et al. [26] 2019 China Randomized controlled tria B Medical clowns perioperative period Cognitive responses;
Divert attention;
Guided imagery;
①④
Yildirim M, et al. [12] 2018 Turkish Randomized controlled tria C Medical clowns dressing changes Guided imagery;
Emotional reflection;
Yan Guifan, et al. [27] 2023 China Randomized controlled tria C Medical clowns dressing changes Divert attention; ①④
Wan Lin, et al. [28] 2023 China Randomized controlled tria D Medical clowns Postoperative fracture and rehabilitation Divert attention;
Cognitive responses
①④
Lopes-Junior LC, et al [29] 2020 Brazil quasi-randomized controlled trial E volunteers Before and after chemotherapy Divert attention; ②④
Shefer S, et al. [30] 2019 Israel Controlled clinical trial F Medical clowns When treating autism Emotional reflection;
Cognitive responses
Bertini, et al. [31] 2011 Italy Randomized controlled tria G Medical clowns When the child was in the hospital room Divert attention
Shauna, et al.[32] 2011 Canada non-randomised controlled trials H Medical clowns When the child was in the hospital room Divert attention
Empowerment;

A children with puncture therapy, B children in perioperative period, C children with burns, D children after fracture surgery, E children with chemotherapy, F children with autism;G Children hospitalized for respiratory pathologies, H disabled children. ①physiological indicators, ②psychological indicators, ③ cognitive-behavioral indicators, ④other indicators.