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. 2024 Dec 9;151(23):dev202868. doi: 10.1242/dev.202868

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© 2024. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Lipidation of Wnt and calcium are required for colocalisation of WNT7A and synaptic markers. (A-C) Antibody staining for WNT7A and LRP6, WNT7A and PSD95, or WNT7A and bassoon (BSN) in iPSC-derived cortical neurons in the absence (A) or presence of the porcupine inhibitor IWP-2 (B), or the calcium chelator EGTA (C). Phn, phalloidin. (D) Quantification of the co-clustering or colocalisation of WNT7A/LRP6, WNT7A/PSD95, and WNT7A/BSN shows dependence on intracellular Wnt trafficking and calcium signalling. Statistical significance was addressed using one-way ANOVA with Dunnett's multiple comparison test to compare relevant controls within groups. ***P<0.005; ****P<0.001.