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. 2024 Dec 9;20(12):e1011485. doi: 10.1371/journal.pgen.1011485

Fig 9. Model of Mec1 and Rad24 activity influencing meiotic DSB formation and repair.

Fig 9

Proposed effects of Rad24 are indicated via dark blue lines, and those of Mec1 via dark red lines. Our results support and contribute to the view that Mec1 influences meiotic recombination in numerous ways: promotion of DSB formation via transient inactivation of Ndt80, suppression of DSB formation in trans, inhibition of hyper-resection, promoting homologue repair, and suppression of class II CO formation. Rad24 may support these roles by promoting Mec1 activation. In addition, Rad24 promotes Zip3-dependent class I CO formation, and/or the process of CO interference propagation, thereby driving the even distribution of COs along and between chromosomes via the process of CO interference. Together these pathways ensure accurate reductional chromosome segregation during meiosis.