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. 2024 Dec 19;19(1):e12058. doi: 10.1002/ccs3.12058

FIGURE 5.

FIGURE 5

ANXA114‐26 promotes apoptosis and reduces MRP1 expression in ovarian cancer cells by inhibiting the FPR/Cyclin D1/NF‐ĸBp65 pathway. (A) The relative expression of Cyclin D1 mRNA. (B) The relative expression of NF‐ĸBp65 mRNA. (C) Protein expression levels of Cyclin D1 and NF‐ĸBp65. (D) The relative expression of Cyclin D1 mRNA. (E) The relative expression of NF‐ĸBp65 mRNA. (F) Protein expression levels of Cyclin D1 and NF‐ĸBp65. (G) Validation of mRNA expression of Cyclin D1 after plasmid transfection. (H) Validation of protein expression of Cyclin D1 after plasmid transfection. (I) The apoptosis of ovarian cancer cells was detected by Annexin V‐FITC/PI assay. (J) The relative expression of BAX mRNA. (K) The relative expression of Bcl‐2 mRNA. (L) The relative expression of MRP1 mRNA. (M) The relative expression of NF‐ĸBp65 mRNA. (N) Protein expression levels of BAX, Bcl‐2, MRP1 and NF‐ĸBp65. The data were independently replicated in triplicate., *p < 0.05, **p < 0.01.