Table 2.

Pathologic features under differentiation landscape.

Differentiation
	Well			Middle			Poor
	N	%	Average	N	%	Average	N	%	Average	P
Subtype
Keratinizing	66	94.3%		129	78.7%		48	52.2%		<0.05
Nonkeratinizing	4	5.7%		34	20.7%		42	45.7%
Basaloid pattern	0	0.0%		1	0.6%		2	2.2%
Tumor budding invasion margin(%)			25.3			30.7			36.3	<0.05
Tumor budding (1HPF)			3.0			3.1			3.8	<0.05
G1	52	78.8%		135	81.8%		59	64.8%		<0.05
G2	13	19.7%		30	18.0%		30	33.0%
G3	1	1.5%		0	0.0%		2	2.2%
Tumor budding (10HPFs)			8.8			10.3			13.0	<0.05
G1	26	39.4%		47	28.8%		21	23.3%		<0.05
G2	19	28.8%		54	33.1%		19	21.1%
G3	21	31.8%		62	38.1%		50	55.6%
Tumor nest-edge
single cell present	42	60.9%		123	74.5%		66	72.5%		NS
nest cells	27	39.1%		42	25.5%		25	27.5%
Tumor nest-entire
single cell present	48	69.6%		140	84.8%		76	83.5%		<0.05
nest cells	21	30.4%		25	15.2%		15	16.5%
Nuclear diameter
≤4 Lymc.	29	41.4%		160	97.0%		85	93.4%		<0.001
≥5Lymc.	41	58.6%		5	3.0%		6	6.6%
Mitotic count			25.0			14.9			17.6	<0.05
<15	28	40.0%		97	59.9%		45	50.6%		<0.05
≥15	42	60.0%		65	40.1%		44	49.4%
Tumor-Stroma Ratio(%)			24.1			25.5			23.6	NS
<50%	60	85.7%		146	88.5%		77	84.6%		NS
≥50%	10	14.3%		19	11.5%		14	15.4%
Invasion depth
submucosa	13	18.6%		17	10.4%		2	2.2%		<0.05
muscularis propria	20	28.6%		90	54.9%		54	60.0%
adventitia	37	52.9%		57	34.8%		34	37.8%
Perineural invasion
No	32	45.7%		87	53.4%		39	42.4%		NS
Yes	38	54.3%		76	46.6%		53	57.6%
Lymphovascular invasion
No	51	72.9%		92	56.1%		41	44.6%		<0.05
Yes	19	27.1%		72	43.9%		51	55.4%

Bold values mean P<0.05.