Table 3.

Pathologic features and their associations with prognosis.

	OS				DFS
	N	%	5-year OS	P	N	%	5-year DFS	P
Subtype
Keratinizing	242	74.5%	48.7%	0.03	241	74.4%	37.8%	0.04
Nonkeratinizing/Basaloid	83	25.5%	39.6%		83	25.6%	28.2%
Tumor budding invasion margin(%)				0.49				0.73
<40	199	61.0%	48.6%		198	60.9%	39.2%
≥40	127	39.0%	44.1%		127	39.1%	29.8%
Tumor budding (1HPF)				0.60				0.23
<5	246	76.4%	47.5%		190	59.2%	39.1%
≥5	76	23.6%	43.3%		131	40.8%	29.6%
Tumor budding (10HPFs)				0.21				0.05
<5	94	29.5%	49.1%		93	29.2%	43.0%
≥5	225	70.5%	45.7%		225	70.8%	33.0%
Tumor nest-edge
single cell present	231	71.1%	46.3%	0.99	231	71.3%	35.3%	0.81
nest cells	94	28.9%	48.0%		93	28.7%	35.7%
Nuclear diameter
≤4 Lymc.	274	84.0%	44.6%	0.07	274	84.3%	32.7%	0.006
≥5 Lymc.	52	16.0%	59.0%		51	15.7%	53.6%
Mitotic count				0.54				0.82
≤15	173	53.9%	45.7%		173	54.1%	35.7
>16	148	46.1%	48.8%		147	45.9%	35.6
Tumor-Stroma Ratio(%)
<50%	283	86.8%	46.4%	0.42	282	86.8%	35.1%	0.23
≥50%	43	13.2%	50.6%		43	13.2%	39.3%
Invasion depth
submucosa/muscularis propria	196	60.5%	48.7%	0.54	195	60.4%	35.4%	0.65
adventitia	128	39.5%	44.4%		128	39.6%	36.3%
Perineural invasion
No	157	48.5%	52.9%	0.01	157	48.6%	40.4%	0.05
Yes	167	51.5%	41.3%		166	51.4%	29.9%
Lymphovascular invasion
No	183	56.3%	55.9%	0.001	182	56.2%	42.0%	0.002
Yes	142	43.7%	36.9%		142	43.8%	28.1%

OS, overall survival; DFS, disease free survival.

Bold values mean P<0.05.