Table 4.

Multivariate analysis of overall survival and disease free survival.

		OS			DFS
		HR	95%CI	P	HR	95%CI	P
Subtype	Keratinizing vs. Nonkeratinizing	1.23	0.87-1.76	0.242	1.14	0.82-1.60	0.446
Tumor budding	<5/HPF vs. ≥5/HPF	0.96	0.65-1.41	0.823	0.88	0.61-1.27	0.476
Tumor budding	<5/10HPF vs. ≥5/10HPF	1.19	0.82-1.74	0.368	1.36	0.94-1.95	0.104
Nuclear diameter	≤4 Lymc. vs. ≥5 Lymc.	0.59	0.36-0.96	0.035	0.48	0.28-0.80	0.005
Perineural invasion	No vs. Yes	1.29	0.92-1.80	0.14	1.16	0.85-1.59	0.358
Lymphovascular invasion	No vs. Yes	1.10	0.78-1.55	0.585	1.04	0.75-1.43	0.823
Pathological stage	II vs. I	0.23	0.09-0.63	0.004	0.14	0.05-0.45	0.001
	III vs. I	0.39	0.28-0.53	<0.001	0.40	0.30-0.54	<0.001

HPF, High power field; Lymc., lymphocytes.

Bold values mean P<0.05.