Table 3.

Required number of events for the composite of time to cardiovascular death or first heart failure hospitalization

	Hazard ratio 0.80	Hazard ratio 0.81	Hazard ratio 0.82
75% Power	558	625	705
80% Power	632	707	797
85% Power	721	809	913
90% Power	844	947	1067

The primary endpoint is incidence rate for total number of heart failure hospitalizations and cardiovascular death, but power is based on time to first cardiovascular death or heart failure hospitalization. The sample size is based on 85% power for a hazard ratio of 0.80, requiring 721 events.

Calculations are from the log‐rank test using nQuery.