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. 2024 Dec 19;7:1669. doi: 10.1038/s42003-024-07342-8

Fig. 8. Delayed transition of thoracic-to-lumbar Hox code in Prtg knockout mice.

Fig. 8

A schematic representation illustrating the process of thoracic-to-lumbar Hox code transition in wild-type and Prtg knockout embryos. Arrows above the Hox genes denote the direction of Hox code translation. In wild-type mice, Prtg interacts with Gdf11 to enhance TGFβ signaling, thereby facilitating the transition of the Hox code from thoracic to lumbar identity, which occurs in the tail region of E9.5 embryos. In Prtg knockout mice, decreased TGFβ signaling results in a delayed transition of the Hox code.