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. 2024 Dec 19;7:1651. doi: 10.1038/s42003-024-07372-2

Fig. 1. Anxiety-like behaviors were evoked two weeks after CFA injection.

Fig. 1

a Schematic of the experimental design. b Gross macroscopic view of left hindpaw after CFA or PBS injection into the left hindpaw of mice. c Statistical results of 50% paw withdrawal thresholds (PWTs). d Statistical results of time spent in the open arms in the EPM test. e Representative images of movement trajectory (top) and activity time (bottom) in the EPM test. f, g Statistical results of time spent in the central area and total distance traveled in the OFT. h Representative images of movement trajectory (top) and activity time (bottom) in the OFT. Data are the mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.01. CFA complete Freund’s adjuvant, EPM elevated plus maze, OFT open field test.