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. 2024 Dec 19;7:1651. doi: 10.1038/s42003-024-07372-2

Fig. 4. BBR alleviated anxiety-like behaviors induced by CFA.

Fig. 4

a Schematic of the experimental design. b Statistical results of 50% paw withdrawal thresholds (PWTs). ***P < 0.001 vs. baseline in the same group. c–e Statistical results of time spent in the open arms in the EPM test and the central area in the OFT after different gradient concentrations of BBR (2.5, 5 and 10 mg/kg/day). Data are the mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, NS not significant. BBR Berberine, CFA complete Freund’s adjuvant, EPM elevated plus maze, OFT open field test.