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. 2024 Dec 19;7:1679. doi: 10.1038/s42003-024-07377-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — A Serum creatinine (SCr) and blood urea nitrogen (BUN) levels continuously increased in I/R model mice. n = 6 mice/group. B Temporal expression patterns of chemerin and CMKLR1 in the kidneys of I/R model mice. n = 3 (independent experiments). C Quantified data for chemerin and CMKLR1 from the western blots shown in (B). D–G Immunofluorescence analysis of chemerin (red; D, F) expression in the renal cortices. Relative immunofluorescence intensities for chemerin are presented in (E) and (G), respectively. AQP1 (green; D) and CK19 (green; F) were used as markers for renal tubular epithelial cells, and DAPI (blue) was used to stain the nuclei. Scale bar = 100 μm. n = 6 mice/group. Serum chemerin (H), blood urea nitrogen (BUN; I), and creatinine (J) levels in healthy individuals and AKI patients. n = 9 humans/group. Spearman correlation analysis between serum chemerin and BUN (K) or creatinine (L). n = 9 humans/group. M Chemerin expression decreased in nephropathy patients. Data analysis from Nephroseq database (https://www.nephroseq.org). Data are presented as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001. One-way ANOVA with Tukey’s multiple comparison test was used for (A) and (C), Student’s t test was used for (E), (G)–(J).