Table 2.

Involved miRNAs in endothelial dysfunction

MiRNA	Disease	Target	Inflammation/Oxidative Stress	Mechanism	Effect on LIF	Ref
MicroRNA-223-3p	AMI	NLRP-3	Anti-inflammatory	Reducing the secretion of IL-1β	Suppressing LIF expression	(70, 81)
MicroRNA-146a	MI	Target IRAK1 & TRAF-6	Anti-inflammatory	Attenuating NFκB activation and inflammatory cytokine production by suppressing IRAK-1 and TRAF-6	Inhibiting the expression of LIF	(82, 83)
MicroRNA-21	MI	KBTBD-7 gene	Anti-inflammatory	Promoting the activation of p38 and NFκB signaling by interacting with MKK3/6	LIF induces the expression of microRNA-21 (miR-21).	(84, 85)
MicroRNA-125a	Atherosclero-sis	ET-1	Anti-inflammatory	Suppressing oxLDL and inducing ET-1 expression	MicroRNA 125a can induce the LIF receptor.	(86, 87)
MicoRNA-146a	Atherosclero-sis	NOX-4	Anti-Inflammation	Inhibiting the activation of TLR4-dependent signaling pathway	Inhibit the expression of LIF	(82, 88)
MicroRNA-141	Atherosclero-sis	PAPP-A	Inflammation	Inhibiting the vascular smooth muscle cell proliferation	LIF can induce the production of microRNA-21.	(89, 90)

AMI, Acute myocardial infarction; NLRP3, NOD-, LRR- and pyrin domain-containing protein 3; MI, Myocardial infarction; IRAK1, Interleukin-1 receptor-associated kinase 1; TRAF-6, TNF receptor-associated factor-6; NFκB, Nuclear factor-kB; ET-1, Endothelin-1; oxLDL, Oxidized LDL; TLR-4, Toll-like receptor-4; PAPP-A, pregnancy-associated plasma protein-A