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. 2025 Jan 1;22(1):71–86. doi: 10.7150/ijms.104932

Figure 6.

Figure 6

Ripk3 knockdown alleviates mitochondrial injury through promoting AMPK-mediated Drp1 phosphorylation. (A-C) The phosphorylation of Drp1 and AMPK was measured using western blots. The AMPK pathway activator, AICAR (AI), was employed to activate AMPK pathway in WT cells under LPS treatment. The AMPK pathway inhibitor, compound C (cC), was utilized to block the AMPK pathway in Ripk3-deficient cells under LPS injury. (D-E) Impact of AMPK on mitochondrial membrane potential. (F) The change of mPTP opening time. Mean ± SEM, ∗p < 0.05 vs. the Ctrl group; #p < 0.05 vs. the LPS group; &p < 0.05 vs. the LPS+AI group; %p< 0.05 vs. the LPS+cC group.