. 2024 Oct 21;4(6):435–442. doi: 10.1021/acsnanoscienceau.4c00052

Table 3. Binding Constants (K), Enantioselectivity, and Reaction Volume Changes (ΔV°) for 1:1 Complexation of Achiral and Chiral Guests with 1 in H₂O under Hydrostatic Pressure at Room Temperature^a.

guest	pressure (MPa)	K^b (M^–1)	K_L/K_D	ΔV° (cm³ mol^–1)
guest	pressure (MPa)	K^b (M^–1)	K_S/K_R	ΔV° (cm³ mol^–1)
1,4-dioxane	0.1	2902 ± 245	^c	1.2 ± 0.3
	40	2924 ± 213
	80	2739 ± 230
	120	2699 ± 237
	160	2662 ± 241
	200	2675 ± 267
l-Phe	40	260 ± 20	1.5	–1.2 ± 0.2
	80	253 ± 21	1.3
	120	264 ± 15	1.4
	160	271 ± 21	1.5
	200	277 ± 23	1.6
	240	276 ± 25	1.3
	280	289 ± 25	1.5
d-Phe	40	178 ± 15	^c	–0.9 ± 0.6
	80	189 ± 19
	120	191 ± 21
	160	186 ± 16
	200	178 ± 22
	240	210 ± 26
	280	193 ± 30
l-Trp	40	1241 ± 141	1.2	–7.0 ± 0.3
	80	1364 ± 115	1.2
	120	1610 ± 119	1.2
	160	1828 ± 146	1.3
	200	1943 ± 94	1.2
	240	2189 ± 168	1.3
	280	2435 ± 180	1.4
d-Trp	40	1016 ± 223	^c	–5.6 ± 0.5
	80	1164 ± 266
	120	1367 ± 281
	160	1428 ± 293
	200	1568 ± 327
	240	1637 ± 344
	280	1795 ± 370
S-2	40	12877 ± 991	6.8	3.5 ± 0.5
	80	13618 ± 1142	7.6
	120	12168 ± 944	6.7
	160	12044 ± 1256	7.2
	200	10878 ± 1541	6.4
	240	10159 ± 1555	6.2
	280	9649 ± 1553	5.9
R-2	40	1903 ± 348	^c	1.5 ± 0.3
	80	1786 ± 315
	120	1812 ± 330
	160	1673 ± 259
	200	1689 ± 365
	240	1648 ± 368
	280	1648 ± 424

All titration experiments were performed in a high-pressure cell.

For convenience, we reported values to the nearest whole number for the lnK-P plots.

Not applicable.

Table 3. Binding Constants (K), Enantioselectivity, and Reaction Volume Changes (ΔV°) for 1:1 Complexation of Achiral and Chiral Guests with 1 in H2O under Hydrostatic Pressure at Room Temperaturea.