Table 3.

Multivariable Hazard Ratios for Exercise and Cause-Specific Mortality

	All-Cause Mortality			Cancer-Specific Mortality			Non-Cancer Mortality
Site	N	N Events	Multivariable HR (95% CI)	N	N Events	Multivariable HR (95% CI)	N	N Events	Multivariable HR (95% CI)
All cancers	10,852	4,397	0.75 (0.70, 0.80)	10,896	1,851	0.79 (0.72, 0.88)	10,852	2,552	0.72 (0.66, 0.78)
Bladder	520	241	0.79 (0.59, 1.04)	524	104	0.85 (0.56, 1.30)	519	137	0.73 (0.49, 1.07)
Breast	2,159	607	0.76 (0.63, 0.91)	2,199	250	0.80 (0.61, 1.06)	2,159	365	0.75 (0.59, 0.96)
Colon	809	351	0.81 (0.63, 1.04)	827	146	1.04 (0.72, 1.50)	817	210	0.68 (0.48, 0.96)
Endometrial	361	95	0.41 (0.24, 0.72)	365	31	0.55 (0.23, 1.34)	361	65	0.41 (0.21, 0.81)
Head & Neck	196	117	0.62 (0.40, 0.96)	196	51	0.49 (0.25, 0.96)	196	66	0.83 (0.47, 1.48)
Hematopoietic	818	458	0.72 (0.59, 0.89)	818	241	0.81 (0.61, 1.07)	826	217	0.62 (0.45, 0.85)
Lung	361	245	1.01 (0.74, 1.38)	362	147	1.00 (0.68, 1.47)	369	101	0.83 (0.50, 1.38)
Melanoma	744	241	0.78 (0.59, 1.02)	745	90	0.74 (0.47, 1.15)	741	151	0.81 (0.57, 1.16)
Ovarian*	109	56	1.04 (0.52, 2.05)	111	47	1.12 (0.55, 2.28)	-	-	-
Prostate	3,980	1,590	0.78 (0.70, 0.86)	4,055	556	0.85 (0.71, 1.02)	4,035	1,052	0.72 (0.63, 0.82)
Renal	234	125	0.50 (0.31, 0.81)	234	56	0.34 (0.15, 0.75)	234	69	0.84 (0.45, 1.58)
Upper GI	92	59	0.87 (0.47, 1.61)	92	28	0.63 (0.26, 1.55)	92	31	1.27 (0.49, 3.28)

HR = Hazard Ratio; CI = Confidence Interval

^*There were only 9 non-cancer deaths among patients with ovarian cancer; the non-cancer mortality model could not be fit for this outcome.

N and N Events shown are based on the multivariable models.

Covariates included in each multivariable model are shown in Supplemental Table 3.